NousEvidence — Influenza High-Risk Populations

Executive View

Consequence Funnel — Population → Death

Every step compresses the cohort into fewer, sicker events. The Investigational Prophylactic counterfactual halves each step by reducing infections upstream.

Risk Tier

Season

Cohort Size

Filter: All US high-risk · 1.0M cohort · Season 2024-25. Current SOC yields 1,171 hospitalizations and 35 deaths.Investigational Prophylactic at 65% uptake × 76% VE brings hospitalizations to 739 (Δ 432 averted).

Consequence Sankey

Node width ∝ event count. Slate = SOC (current), Gold = Investigational Prophylactic counterfactual.

Widths recompute in real time when you change filters or the Investigational Prophylactic lens above.

Vertical Consequence Pyramid

Side-by-side SOC vs Investigational Prophylactic pyramids

SOC

1.0M

Population

Infected

Medically attended

Hospitalized

ICU

Mech. ventilation

Death

Investigational Prophylactic

1.0M

Population

Infected

Medically attended

Hospitalized

ICU

Mech. ventilation

Death

Investigational Prophylactic pyramid narrows earlier because more people never get infected in the first place.

Clinical burden — depth

ICU Length of Stay Distribution — Hospitalized

P25 · median · P75 · P90 · maximum by high-risk tier

IC and multi-morbid patients drive the extreme tail — median ~9 days but max >60 days in HSCT recipients.

Mechanical Ventilation + ECMO Share

Among ICU-admitted patients by tier

ECMO utilization rises with immunocompromise — reflecting refractory ARDS in HSCT and CAR-T recipients.

Pediatric Burden — Age Stratified

Hosp rate per 100K · Neuro complication share · Mortality

Infants <6 months have the highest pediatric hosp rate. High-risk adolescents have adult-level burden.