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Influenza in U.S. High-Risk Populations · Systematic Evidence Curation 2016–2026

Live · 2026-07-09
§ 222 studies
1523 endpoints
Investigational Prophylactic lens
Real-World Data

Synthetic RWD Cohort Explorer

Explore hospitalization rates, ICU %, mortality, and cost by high-risk tier and US census division.

Cohort composition
The cohort represents US adults across the four high-risk tiers (severely IC, moderately IC, comorbid, ≥65y) plus general adults. Every rate reflects published US real-world evidence and is one click from its underlying PMIDs.
Cohort size
50,000
Patients
Seasons
10
2016–2025
Flu episodes
40,422
All tiers × seasons
Investigational Prophylactic target VE
76%
Applied per patient

Hospitalization rate by tier

Synthetic patients per season × tier (per 100K)

Cohort characteristics table

Rates and costs per tier

TierNHosp / 100KICU %Mortality %Mean cost / eventMean LOS
Adults ≥65182,09046815.6%2.70%$1,3684.0 d
Comorbid105,14082020.5%3.60%$2,0904.5 d
General202,87017615.9%1.68%$7404.3 d
Moderately IC6,941174321.5%3.31%$3,6055.6 d
Severely IC2,899400134.5%8.62%$6,7338.2 d

Division breakdown

Patient counts by US census division